HCG 10000iu
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What is HCG 10000iu?
Human Chorionic Gonadotropin (HCG) is a naturally occurring placental glycoprotein hormone that binds to and activates the luteinizing hormone/choriogonadotropin receptor (LHCGR). It is structurally similar to luteinizing hormone (LH), but contains unique features that prolong its half-life and biochemical activity.
In research environments, HCG is widely used to study:
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Luteinizing hormone receptor signaling
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Reproductive endocrinology
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Steroidogenesis
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Paracrine communication
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Angiogenesis and cellular development
This product is intended for laboratory and scientific research use only.
Chemical Structure of HCG 10000iu
HCG is a heterodimeric glycoprotein hormone, approximately 37.9 kDa, composed of two subunits:
• Alpha (α) Subunit – 92 amino acids
Shared with LH, FSH, and TSH.
Contains two N-linked glycosylation sites.
• Beta (β) Subunit – 145 amino acids
Unique to HCG.
Includes an extended C-terminal peptide (CTP) of 24 amino acids, responsible for increasing its half-life.
Contains two N-linked and four O-linked glycosylation sites.
Key Structural Features
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~30% carbohydrate content — improves stability and biological persistence
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Eight total sugar chains
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Cystine-knot motif with three disulfide bonds per subunit, providing structural rigidity essential for receptor binding
This complex structural arrangement gives HCG high receptor affinity and long-lasting signaling capability.
What Are the Effects of HCG 10000iu?
Preclinical and in-vitro research demonstrates that HCG participates in several biological pathways:
• LHCGR-Mediated Signaling
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Activates Gs and Gq protein pathways
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Stimulates cAMP production
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Promotes steroidogenesis in gonadotrophin-responsive cells
• Angiogenic & Paracrine Activity
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Induces endothelial cells to release VEGF and other angiogenic factors
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Supports tissue vascularization in experimental models
• Reproductive Endocrine Modulation
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Enhances progesterone secretion
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Supports oocyte maturation
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Aids in early embryonic development (in research contexts)
• Biased Agonism
HCG produces unique signaling kinetics compared to LH:
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More sustained cAMP responses
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Distinct gene-expression patterns
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Longer duration of receptor activation
These characteristics make HCG a valuable tool for studying differential LHCGR signaling.
Research-Use Disclaimer
HCG 10,000 IU is supplied strictly for laboratory, educational, and scientific research purposes.
It is not intended for human or veterinary administration.
HCG 10000iu
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2026-01-20
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